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Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.

5'-Deoxy-5'-methylthioadenosine phosphorylase (methylthioadeno-sine: ortho-phosphate methylthioribosyltransferase, EC 24.2.28; MTAP) plays a role in purine and polyamine metabolism and in the regulation of transmethylation reactions. MTAP is abundant in normal cells but is deficient in many cancers....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Nobori, T, Takabayashi, K, Tran, P, Orvis, L, Batova, A, Yu, A L, Carson, D A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39214/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650244/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.6203
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