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Investigation of Behavior of Forced Degradation of Lidocaine HCl by NMR Spectroscopy and GC-FID Methods: Validation of GC-FID Method for Determination of Related Substance in Pharmaceutical Formulations

The forced degradation study of lidocaine HCl was carried out according to the ICH guideline Q1A (R2). The degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by GC-FID method and nuclear magnetic...

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Bibliographische Detailangaben
Hauptverfasser: Kadioglu, Yucel, Atila, Alptug, Serdar Gultekin, Mehmet, Alcan Alp, Nurdan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Shaheed Beheshti University of Medical Sciences 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920691/
https://ncbi.nlm.nih.gov/pubmed/24523745
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