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Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.

Previous studies suggest that the conjugation of ubiquitin to NH2 groups of proteins is required for protein breakdown. We now show that the selective modification of NH2-terminal alpha-NH2 groups of globin and lysozyme prevents their degradation by the ubiquitin proteolytic system from reticulocyte...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Hershko, A, Heller, H, Eytan, E, Kaklij, G, Rose, I A
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1984
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392068/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6095265/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.22.7021
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