USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and de...

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Bibliographic Details
Main Authors: Fan, Yihui, Mao, Renfang, Yu, Yang, Liu, Shangfeng, Shi, Zhongcheng, Cheng, Jin, Zhang, Huiyuan, An, Lei, Zhao, Yanling, Xu, Xin, Chen, Zhenghu, Kogiso, Mari, Zhang, Dekai, Zhang, Hong, Zhang, Pumin, Jung, Jae U., Li, Xiaonan, Xu, Guotong, Yang, Jianhua
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920558/
https://ncbi.nlm.nih.gov/pubmed/24493797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122844
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