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The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases

The Cytotoxic Necrotizing Factor 1 (CNF1), a protein toxin from pathogenic E. coli, modulates the Rho GTPases, thus, directing the organization of the actin cytoskeleton. In the nervous system, the Rho GTPases play a key role in several processes, controlling the morphogenesis of dendritic spines an...

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Main Authors: Travaglione, Sara, Loizzo, Stefano, Ballan, Giulia, Fiorentini, Carla, Fabbri, Alessia
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920261/
https://ncbi.nlm.nih.gov/pubmed/24402235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins6010270
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