Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3

Microvascular insufficiency contributes to cardiac hypertrophy and worsens heart dysfunction in diabetic cardiomyopathy. Our recent study shows that apelin may protect ischemic heart failure via upregulation of sirtuin 3 (Sirt3) and angiogenesis. This study investigated whether apelin promotes angio...

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Detalhes bibliográficos
Main Authors: Zeng, Heng, He, Xiaochen, Hou, Xuwei, Li, Lanfang, Chen, Jian-Xiong
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920238/
https://ncbi.nlm.nih.gov/pubmed/24363305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00821.2013
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