Tolvaptan as a tool in renal physiology

For decades, the Brattleboro rat has been a useful model in kidney physiology. These animals manifest central diabetes insipidus (lack of circulating vasopressin) due to a mutation in the vasopressin-neurophysin gene. V2 receptor-mediated vasopressin actions in the kidney can be assessed in these an...

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Bibliographic Details
Main Authors: Miranda, Carlos A., Lee, Jae Wook, Chou, Chung-Lin, Knepper, Mark A.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
Subjects:
Innovative Methodology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920050/
https://ncbi.nlm.nih.gov/pubmed/24305472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00330.2013
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