Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2

Type 2 diabetes is characterized by dyslipidemia with elevated free fatty acids (FFAs). Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes are susceptible to saturated FFAs, which induce endoplasmic reticulum (ER) stress and podocyte death. Genome-wide association studies indicat...

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Bibliografiske detaljer
Main Authors: Kampe, Kapil, Sieber, Jonas, Orellana, Jana Marina, Mundel, Peter, Jehle, Andreas Werner
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
Fag:
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920022/
https://ncbi.nlm.nih.gov/pubmed/24338821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00454.2013
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