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Ligand placement based on prior structures: the guided ligand-replacement method
The process of iterative structure-based drug design involves the X-ray crystal structure determination of upwards of 100 ligands with the same general scaffold (i.e. chemotype) complexed with very similar, if not identical, protein targets. In conjunction with insights from computational models and...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
International Union of Crystallography
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919265/ https://ncbi.nlm.nih.gov/pubmed/24419386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004713030071 |
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