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Comparison of the isomerization mechanisms of human melanopsin and invertebrate and vertebrate rhodopsins

Comparative modeling and ab initio multiconfigurational quantum chemistry are combined to investigate the reactivity of the human nonvisual photoreceptor melanopsin. It is found that both the thermal and photochemical isomerization of the melanopsin 11-cis retinal chromophore occur via a space-savin...

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Main Authors: Rinaldi, Silvia, Melaccio, Federico, Gozem, Samer, Fanelli, Francesca, Olivucci, Massimo
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918805/
https://ncbi.nlm.nih.gov/pubmed/24449866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309508111
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