Assessment of Mycobacterium bovis Deleted in p27-p55 Virulence Operon as Candidate Vaccine against Tuberculosis in Animal Models

A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models. The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs us...

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Detalhes bibliográficos
Main Authors: Bianco, María V., Clark, Simon, Blanco, Federico C., Garbaccio, Sergio, García, Elizabeth, Cataldi, Angel A., Williams, Ann, Bigi, Fabiana
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918748/
https://ncbi.nlm.nih.gov/pubmed/24588000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/951978
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