Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice

AIMS/HYPOTHESIS: Adult beta cells have a diminished ability to proliferate. Phosphatase and tensin homologue (PTEN) is a lipid phosphatase that antagonises the function of the mitogenic phosphatidylinositol 3-kinase (PI3K) pathway. The objective of this study was to understand the role of PTEN and P...

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Bibliographic Details
Main Authors: Yang, Kai-Ting, Bayan, Jennifer-Ann, Zeng, Ni, Aggarwal, Richa, He, Lina, Peng, Zhechu, Kassa, Anketse, Kim, Melissa, Luo, Zhiou, Shi, Zhenrong, Medina, Vivian, Boddupally, Keerthi, Stiles, Bangyan L.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918745/
https://ncbi.nlm.nih.gov/pubmed/24162585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-3085-8
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