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A Novel Method for the Rapid and Specific Post-synthesis Modification of DNA via a Biocompatible Condensation of 1, 2-Aminothiols with 2-Cyanobenzothiazole
Post-synthesis modification of DNA is an important way of functionalizing DNA molecules. Herein we describe a method that first enzymatically incorporates a cyanobenzothiazole (CBT)-modified thymidine. The side chain handle CBT can undergo a rapid and site-specific cyclization reaction with 1,2-amin...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3918485/ https://ncbi.nlm.nih.gov/pubmed/23447494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201201677 |
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