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Randomised clinical trial: individualized versus weight-based dosing of azathioprine in crohn’s disease
BACKGROUND: Azathioprine (AZA), a pro-drug metabolized to the active metabolites 6-thioguanine nucleotides (6TGN), is a steroid-sparing therapy for Crohn’s disease (CD). This trial investigated whether AZA therapy is optimized by individualized dosing based on thiopurine methyltransferase (TPMT) act...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3918445/ https://ncbi.nlm.nih.gov/pubmed/24237037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.12555 |
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