Leukotriene B4 mobilizes calcium without the breakdown of polyphosphoinositides and the production of phosphatidic acid in rabbit neutrophils.

The addition of fMet-Leu-Phe, leukotriene B4, or arachidonic acid to rabbit neutrophils causes a rise in the level of intracellular free calcium as measured by the fluorescent dye quin-2. The calcium response is rapid and dose-dependent with an ED50 of 0.12 +/- 0.05 nM for leukotriene B4, 0.20 +/- 0...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Volpi, M, Yassin, R, Tao, W, Molski, T F, Naccache, P H, Sha'afi, R I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1984
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391839/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6091126/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.19.5966
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