Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

The mammalian form of the protozoan parasite Leishmania mexicana contains high activity of a cysteine proteinase (LmCPb) encoded on a tandem array of 19 genes (lmcpb). Homozygous null mutants for lmcpb have been produced by targeted gene disruption. All life-cycle stages of the mutant can be culture...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Mottram, J C, Souza, A E, Hutchison, J E, Carter, R, Frame, M J, Coombs, G H
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39179/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8650210/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.12.6008
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