TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiation therapy

Cancer radiotherapy may be immunogenic, but it is unclear why its immunogenic effects are rarely sufficient to prevent tumor recurrence. Here we report a novel Toll receptor-9 (TLR9)-dependent mechanism that initiates tumor regrowth after local radiotherapy. Systemic inhibition of TLR9, but not TLR4...

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Main Authors: Gao, Chan, Kozlowska, Anna, Nechaev, Sergey, Li, Haiqing, Zhang, Qifang, Hossain, Dewan M. S., Kowolik, Claudia M., Chu, Peiguo, Swiderski, Piotr, Diamond, Don J., Pal, Sumanta K., Raubitschek, Andrew, Kortylewski, Marcin
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917779/
https://ncbi.nlm.nih.gov/pubmed/24154870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1314
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