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Genomic insights into WNT/β-catenin signaling

The canonical WNT pathway regulates the stability of the proto-oncogene β-catenin and is aberrantly activated in many cancer types. Studies in a wide range of experimental models confirm that β-catenin activity is required for tumor initiation in cancers where this pathway is deregulated. However, t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Rosenbluh, Joseph, Wang, Xiaoxing, Hahn, William C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917662/
https://ncbi.nlm.nih.gov/pubmed/24365576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2013.11.007
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