Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome

PURPOSE: Lynch syndrome is an autosomal dominant syndrome of familial malignancies resulting from germ-line mutations in DNA mismatch repair (MMR) genes. Our goal was to take a pathway-based approach to investigate the influence of polymorphisms in cell-cycle related genes on age of onset for Lynch...

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Main Authors: Chen, Jinyun, Etzel, Carol J., Amos, Christopher I., Zhang, Qing, Viscofsky, Nancy, Lindor, Noralane M., Lynch, Patrick M., Frazier, Marsha L.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917505/
https://ncbi.nlm.nih.gov/pubmed/19690970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-009-9416-x
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