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Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome
PURPOSE: Lynch syndrome is an autosomal dominant syndrome of familial malignancies resulting from germ-line mutations in DNA mismatch repair (MMR) genes. Our goal was to take a pathway-based approach to investigate the influence of polymorphisms in cell-cycle related genes on age of onset for Lynch...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3917505/ https://ncbi.nlm.nih.gov/pubmed/19690970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10552-009-9416-x |
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