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cDNA clone for the alpha-chain of human beta-hexosaminidase: deficiency of alpha-chain mRNA in Ashkenazi Tay-Sachs fibroblasts.

We have isolated a cDNA clone containing sequences complementary to mRNA encoding the alpha-chain of the lysosomal enzyme beta-hexosaminidase. RNA from a human lung fibroblast strain, IMR90, was enriched for beta-hexosaminidase messenger by polysome immunoselection with antiserum against beta-hexosa...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Myerowitz, R, Proia, R L
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1984
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Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391710/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6236461/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.17.5394
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