Dysregulated D-dopachrome Tautomerase, a Hypoxia-inducible Factor-dependent Gene, Cooperates with Macrophage Migration Inhibitory Factor in Renal Tumorigenesis

Clear cell renal cell carcinomas (ccRCCs) are characterized by biallelic loss of the von Hippel-Lindau tumor suppressor and subsequent constitutive activation of the hypoxia-inducible factors, whose transcriptional programs dictate major phenotypic attributes of kidney tumors. We recently described...

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Detalhes bibliográficos
Main Authors: Pasupuleti, Vinay, Du, Weinan, Gupta, Yashi, Yeh, I-Ju, Montano, Monica, Magi-Galuzzi, Cristina, Welford, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916569/
https://ncbi.nlm.nih.gov/pubmed/24356968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.500694
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