Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

Cells respond to suboptimal microenvironments by activating stress signaling pathways, like the unfolded protein response and hypoxia-induced transcription factors HIF-1/2, to restore homeostasis. Both cytoprotective pathways have been well studied in isolation at the biochemical and molecular level...

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Detalhes bibliográficos
Main Authors: Pereira, Ethel R., Frudd, Karen, Awad, Walid, Hendershot, Linda M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916539/
https://ncbi.nlm.nih.gov/pubmed/24347168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507194
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