Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

Intrinsic resistance to cytotoxic drugs has been a main issue in cancer therapy for decades. Microenvironmental acidity is a simple while highly efficient mechanism of chemoresistance, exploited through impairment of drug delivery. The latter is achieved by extracellular protonation and/or sequestra...

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Detalhes bibliográficos
Main Authors: Federici, Cristina, Petrucci, Francesco, Caimi, Stefano, Cesolini, Albino, Logozzi, Mariantonia, Borghi, Martina, D'Ilio, Sonia, Lugini, Luana, Violante, Nicola, Azzarito, Tommaso, Majorani, Costanza, Brambilla, Daria, Fais, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916404/
https://ncbi.nlm.nih.gov/pubmed/24516610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088193
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