Guinea pig preproinsulin gene: an evolutionary compromise?

We characterized a clone carrying the guinea pig preproinsulin gene, which, in contrast to other mammalian preproinsulin genes, is highly divergent in its regions encoding the B and A chains of mature insulin. Blot hybridization analysis indicates that this gene is present in only one copy in the gu...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Chan, S J, Episkopou, V, Zeitlin, S, Karathanasis, S K, MacKrell, A, Steiner, D F, Efstratiadis, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391634/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6591179/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.16.5046
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