Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24

Old English Sheepdogs and Gordon Setters suffer from a juvenile onset, autosomal recessive form of canine hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex. The clinical and histological characteristics are analogous to hereditary ataxias in humans. Linkage and genom...

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Auteurs principaux: Agler, Caryline, Nielsen, Dahlia M., Urkasemsin, Ganokon, Singleton, Andrew, Tonomura, Noriko, Sigurdsson, Snaevar, Tang, Ruqi, Linder, Keith, Arepalli, Sampath, Hernandez, Dena, Lindblad-Toh, Kerstin, van de Leemput, Joyce, Motsinger-Reif, Alison, O'Brien, Dennis P., Bell, Jerold, Harris, Tonya, Steinberg, Steven, Olby, Natasha J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916225/
https://ncbi.nlm.nih.gov/pubmed/24516392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003991
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