Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel Ca(V)2.2 pre-mRNA

Presynaptic voltage-gated calcium Ca(V)2.2 channels play a privileged role in spinal level sensitization following peripheral nerve injury. Direct and indirect inhibitors of Ca(V)2.2 channel activity in spinal dorsal horn are analgesic in chronic pain states. Ca(V)2.2 channels represent a family of...

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Bibliographic Details
Main Authors: Jiang, Yu-Qiu, Andrade, Arturo, Lipscombe, Diane
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916075/
https://ncbi.nlm.nih.gov/pubmed/24369063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-9-67
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