Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer

Understanding the origins of resistance to anti-oestrogen drugs is of critical importance to many breast cancer patients. Recent experiments show that knockdown of GRP78, a key gene in the unfolded protein response (UPR), can re-sensitize resistant cells to anti-oestrogens, and overexpression of GRP...

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Autori principali: Parmar, Jignesh H., Cook, Katherine L., Shajahan-Haq, Ayesha N., Clarke, Pamela A. G., Tavassoly, Iman, Clarke, Robert, Tyson, John J., Baumann, William T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society 2013
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915832/
https://ncbi.nlm.nih.gov/pubmed/24511377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsfs.2013.0012
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