Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IREα

Growing evidence supports a role for the unfolded protein response (UPR) in carcinogenesis; however, the precise molecular mechanisms underlying this phenomenon remain elusive. Herein, we identified the circadian clock PER1 mRNA as a novel substrate of the endoribonuclease activity of the UPR sensor...

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Main Authors: Pluquet, Olivier, Dejeans, Nicolas, Bouchecareilh, Marion, Lhomond, Stephanie, Pineau, Raphael, Higa, Arisa, Delugin, Maylis, Combe, Chantal, Loriot, Sandrine, Cubel, Gaelle, Dugot-Senant, Nathalie, Vital, Anne, Loiseau, Hugues, Gosline, Sara J. C., Taouji, Said, Hallett, Michael, Sarkaria, Jann N., Anderson, Keith, Wu, Wenting, Rodriguez, Fausto J., Rosenbaum, Jean, Saltel, Frédéric, Fernandez-Zapico, Martin E., Chevet, Eric
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915716/
https://ncbi.nlm.nih.gov/pubmed/23752693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-3989
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