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Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells

The androgen receptor (AR) stimulates and represses gene expression to promote the initiation and progression of prostate cancer. Here we report that androgen represses the miR-99a/let7c/125b-2 cluster through AR and anti-androgen drugs block the androgen-repression of the miRNA cluster. AR directly...

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Detalhes bibliográficos
Main Authors: Sun, Dandan, Layer, Ryan, Mueller, Adam C., Cichewicz, Magdalena A., Negishi, Masamitsu, Paschal, Bryce M., Dutta, Anindya
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915043/
https://ncbi.nlm.nih.gov/pubmed/23503464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.77
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