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PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas

BACKGROUND AND AIMS: Recent studies have reported high frequencies of somatic mutations in the phosphoinositide-3-kinase catalytic-α (PIK3CA) gene in various human tumors. Three hot-spot mutations in the exons 9 and 20 have been proven to activate the Akt signalling pathway. The Raf/MEK/ERK (mitogen...

詳細記述

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書誌詳細
主要な著者: Schönleben, Frank, Qiu, Wanglong, Remotti, Helen E., Hohenberger, Werner, Su, Gloria H.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915028/
https://ncbi.nlm.nih.gov/pubmed/18343945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00423-008-0285-7
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