High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

Toxicity is a major cause of failure in drug discovery and development, and whilst robust toxicological testing occurs, efficiency could be improved if compounds with cytotoxic characteristics were identified during primary compound screening. The use of high-content imaging in primary screening is...

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Detalhes bibliográficos
Main Authors: Martin, Heather L., Adams, Matthew, Higgins, Julie, Bond, Jacquelyn, Morrison, Ewan E., Bell, Sandra M., Warriner, Stuart, Nelson, Adam, Tomlinson, Darren C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914966/
https://ncbi.nlm.nih.gov/pubmed/24505478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088338
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