Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin

BACKGROUND: Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α improves skeletal muscle function in the murine...

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Autors principals: Chan, Mun Chun, Rowe, Glenn C, Raghuram, Srilatha, Patten, Ian S, Farrell, Caitlin, Arany, Zolt
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914847/
https://ncbi.nlm.nih.gov/pubmed/24447845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2044-5040-4-2
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