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Power analysis for case–control association studies of samples with known family histories
Genome-wide case–control studies have been widely used to identify genetic variants that predispose to human diseases. Such studies are powerful in detecting common genetic variants with moderate effects, but quickly lose power as allele frequency and genotype relative risk decrease. Because patient...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3914772/ https://ncbi.nlm.nih.gov/pubmed/20383776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-010-0824-5 |
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