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Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis
A single somatic mutation, V617F, in Janus kinase 2 (JAK2) is one of the causes of myeloproliferative neoplasms (MPNs), including primary myelofibrosis, and the JAK2V617F mutant kinase is a therapeutic target in MPN. However, inhibition of wild-type (WT) JAK2 can decrease the erythrocyte or platelet...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3913942/ https://ncbi.nlm.nih.gov/pubmed/24413068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.73 |
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