Vaccination of Mice Using the West Nile Virus E-Protein in a DNA Prime-Protein Boost Strategy Stimulates Cell-Mediated Immunity and Protects Mice against a Lethal Challenge

West Nile virus (WNV) is a mosquito-borne flavivirus that is endemic in Africa, the Middle East, Europe and the United States. There is currently no antiviral treatment or human vaccine available to treat or prevent WNV infection. DNA plasmid-based vaccines represent a new approach for controlling i...

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Main Authors: De Filette, Marina, Soehle, Silke, Ulbert, Sebastian, Richner, Justin, Diamond, Michael S., Sinigaglia, Alessandro, Barzon, Luisa, Roels, Stefan, Lisziewicz, Julianna, Lorincz, Orsolya, Sanders, Niek N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913677/
https://ncbi.nlm.nih.gov/pubmed/24503579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087837
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