Development of a Human Dihydroorotate Dehydrogenase (hDHODH) Pharma-Similarity Index Approach with Scaffold-Hopping Strategy for the Design of Novel Potential Inhibitors

Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. Because it is extensively used by proliferating cells, its inhibition in autoimmune and inflammatory diseases, cancers, and multiple sclerosis is of substantial clinical importance. In this study, we had two aims....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shih, Kuei-Chung, Lee, Chi-Ching, Tsai, Chi-Neu, Lin, Yu-Shan, Tang, Chuan-Yi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913663/
https://ncbi.nlm.nih.gov/pubmed/24504131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087960
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