Gene amplification: an example of accelerated evolution in tumorigenic cells.

During selection for methotrexate resistance, tumorigenic CHEF/16 cells and derivatives from CHEF/16 tumors underwent amplification of the dihydrofolate reductase gene (DHFR) at accelerated rates compared with closely related nontumorigenic CHEF/18 cells. "Dot blot" analysis showed that the CHEF/16...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Sager, R, Gadi, I K, Stephens, L, Grabowy, C T
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1985
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391300/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3863138/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.20.7015
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