Identification and order of sequential mutations in beta-actin genes isolated from increasingly tumorigenic human fibroblast strains.
We have sequenced the mutant beta-actin gene of a tumorigenic human fibroblast cell line (HuT-14T) and found that it carries three mutations that alter the amino acids at positions 36, 83, and 244 as well as a 22-base-pair "insertion" sequence, in the 5' intron, not present in a wild-type gene. The...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1985
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391296/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2996000/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.20.6995 |
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