Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo

Vitiligo is an autoimmune disease characterized by destruction of melanocytes, leaving 0.5% of the population with progressive depigmentation. Current treatments offer limited efficacy. We report that modified inducible heat shock protein 70 (HSP70i) prevents T cell–mediated depigmentation. HSP70i i...

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Hlavní autoři: Mosenson, Jeffrey A., Zloza, Andrew, Nieland, John D., Garrett-Mayer, Elizabeth, Eby, Jonathan M., Huelsmann, Erica J., Kumar, Previn, Denman, Cecele J., Lacek, Andrew T., Kohlhapp, Frederick J., Alamiri, Ahmad, Hughes, Tasha, Bines, Steven D., Kaufman, Howard L., Overbeck, Andreas, Mehrotra, Shikhar, Hernandez, Claudia, Nishimura, Michael I., Guevara-Patino, Jose A., Le Poole, I. Caroline
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912753/
https://ncbi.nlm.nih.gov/pubmed/23447019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005127
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