Controlling stereoselectivity by enzymatic and chemical means to access enantiomerically pure (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivatives()

A chemoenzymatic strategy for the synthesis of enantiomerically pure novel alkaloids (1S,3R)-1-benzyl-2,3-dimethyl-1,2,3,4-tetrahydroisoquinolines is presented. The key steps are the biocatalytic stereoselective reductive amination of substituted 1-phenylpropan-2-one derivatives to yield chiral amin...

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Hlavní autoři: Orden, Alejandro A., Schrittwieser, Joerg H., Resch, Verena, Mutti, Francesco G., Kroutil, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912595/
https://ncbi.nlm.nih.gov/pubmed/24503964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetasy.2013.05.003
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