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Do agonists promote rapid internalization of beta-adrenergic receptors?

We used elution of radioligands at low pH to quantitate intracellular beta-adrenergic receptors on intact S49 lymphoma cells. We validated this method with respect to cell viability, beta-adrenergic receptor integrity, and transferrin receptors on these cells. On control cells, about 15% of the radi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mahan, L C, Motulsky, H J, Insel, P A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391250/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2864689/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.19.6566
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