Structure Dependent Binding of Arylimidamides to the DNA Minor Groove

Heterocyclic diamidines are strong DNA minor groove binders and have excellent antiparasitic activity. To extend the biological activity of these compounds, a series of arylimidamides (AIAs) analogs, which have better uptake properties in Leishmania and T. cruizi than diamidines, was prepared. The b...

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Bibliographic Details
Main Authors:	Chai, Yun, Munde, Manoj, Kumar, Arvind, Mickelson, Leah, Lin, Sen, Campbell, Nancy H., Banerjee, Moloy, Akay, Senol, Liu, Zongying, Farahat, Abdelbasset A., Nhili, Raja, Depauw, Sabine, David-Cordonnier, Marie-Hélène, Neidle, Stephen, Wilson, W. David, Boykin, David W.
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3912452/ https://ncbi.nlm.nih.gov/pubmed/24323836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300622
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Structure Dependent Binding of Arylimidamides to the DNA Minor Groove

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