Mechanisms of hydroxylation by cytochrome P-450: metabolism of monohalobenzenes by phenobarbital-induced microsomes.

The monohydroxylation of halobenzenes by phenobarbital-induced rat liver microsomes was studied. The p-halophenol was found to be the major metabolite from all four halobenzenes; o-halophenol formation decreased as the halogen atom size increased. Vmax for total hydroxylation (ortho and para product...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Burka, L T, Plucinski, T M, Macdonald, T L
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1983
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6579552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.21.6680
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