IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

Obesity is associated with the development of asthma and considerable asthma-related healthcare utilization. To understand the immunological pathways that lead to obesity-associated asthma, we fed mice a high fat diet for 12 weeks, which resulted in obesity and the development of airway hyperreactiv...

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Main Authors: Kim, Hye Young, Lee, Hyun Jun, Chang, Ya-Jen, Pichavant, Muriel, Shore, Stephanie A., Fitzgerald, Katherine A., Iwakura, Yoichiro, Israel, Elliot, Bolger, Kenneth, Faul, John, DeKruyff, Rosemarie H., Umetsu, Dale T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912313/
https://ncbi.nlm.nih.gov/pubmed/24336249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3423
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