Smoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD Risk Locus 19q13.2

Genome-wide association studies (GWAS) and candidate gene studies have identified a number of risk loci associated with the smoking-related disease COPD, a disorder that originates in the airway epithelium. Since airway basal cell (BC) stem/progenitor cells exhibit the earliest abnormalities associa...

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Hlavní autoři: Ryan, Dorothy M., Vincent, Thomas L., Salit, Jacqueline, Walters, Matthew S., Agosto-Perez, Francisco, Shaykhiev, Renat, Strulovici-Barel, Yael, Downey, Robert J., Buro-Auriemma, Lauren J., Staudt, Michelle R., Hackett, Neil R., Mezey, Jason G., Crystal, Ronald G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912203/
https://ncbi.nlm.nih.gov/pubmed/24498427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088051
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