A GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes

GNAS, a gene encoding G protein stimulating α subunit, is frequently mutated in intraductal papillary mucinous neoplasms (IPMNs), which are indolent and slow-growing pancreatic tumors that secrete abundant mucin. The GNAS mutation is not observed in conventional ductal adenocarcinomas of the pancrea...

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Main Authors: Komatsu, Hirotake, Tanji, Etsuko, Sakata, Naoaki, Aoki, Takeshi, Motoi, Fuyuhiko, Naitoh, Takeshi, Katayose, Yu, Egawa, Shinichi, Unno, Michiaki, Furukawa, Toru
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912139/
https://ncbi.nlm.nih.gov/pubmed/24498386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087875
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