The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies

The activity of the epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab in metastatic colorectal carcinoma (mCRC) is significantly limited by molecular mechanisms leading to intrinsic or acquired resistance. The S492R mutation of the EGFR, which is caused by either the 1476C...

詳細記述

保存先:
書誌詳細
主要な著者: Esposito, Claudia, Rachiglio, Anna Maria, La Porta, Maria Libera, Sacco, Alessandra, Roma, Cristin, Iannaccone, Alessia, Tatangelo, Fabiana, Forgione, Laura, Pasquale, Raffaella, Barbaro, Americo, Botti, Gerardo, Ciardiello, Fortunato, Normanno, Nicola
フォーマット: Artigo
言語:Inglês
出版事項: Landes Bioscience 2013
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912037/
https://ncbi.nlm.nih.gov/pubmed/24025416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26340
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料