The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal carcinoma before exposure to EGFR monoclonal antibodies

The activity of the epidermal growth factor receptor (EGFR) antibodies cetuximab and panitumumab in metastatic colorectal carcinoma (mCRC) is significantly limited by molecular mechanisms leading to intrinsic or acquired resistance. The S492R mutation of the EGFR, which is caused by either the 1476C...

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Detalhes bibliográficos
Main Authors: Esposito, Claudia, Rachiglio, Anna Maria, La Porta, Maria Libera, Sacco, Alessandra, Roma, Cristin, Iannaccone, Alessia, Tatangelo, Fabiana, Forgione, Laura, Pasquale, Raffaella, Barbaro, Americo, Botti, Gerardo, Ciardiello, Fortunato, Normanno, Nicola
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912037/
https://ncbi.nlm.nih.gov/pubmed/24025416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.26340
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