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Retrovirus-Specific Differences in Matrix and Nucleocapsid Protein-Nucleic Acid Interactions: Implications for Genomic RNA Packaging

Retroviral RNA encapsidation involves a recognition event between genomic RNA (gRNA) and one or more domains in Gag. In HIV-1, the nucleocapsid (NC) domain is involved in gRNA packaging and displays robust nucleic acid (NA) binding and chaperone functions. In comparison, NC of human T-cell leukemia...

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Main Authors: Sun, Meng, Grigsby, Iwen F., Gorelick, Robert J., Mansky, Louis M., Musier-Forsyth, Karin
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911680/
https://ncbi.nlm.nih.gov/pubmed/24227839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02151-13
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