Palmitoylation and p8-Mediated Human T-Cell Leukemia Virus Type 1 Transmission

The orf-I gene of human T-cell leukemia type 1 (HTLV-1) encodes p8 and p12 and has a conserved cysteine at position 39. p8 and p12 form disulfide-linked dimers, and only the monomeric forms of p8 and p12 are palmitoylated. Mutation of cysteine 39 to alanine (C39A) abrogated dimerization and palmitoy...

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Autori principali: Edwards, Dustin, Fukumoto, Risaku, de Castro-Amarante, Maria Fernanda, Alcantara, Luiz Carlos Junior, Galvão-Castro, Bernardo, Washington Parks, Robyn, Pise-Masison, Cynthia, Franchini, Genoveffa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911539/
https://ncbi.nlm.nih.gov/pubmed/24284316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03444-13
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