High-Multiplicity HIV-1 Infection and Neutralizing Antibody Evasion Mediated by the Macrophage-T Cell Virological Synapse

Macrophage infection is considered to play an important role in HIV-1 pathogenesis and persistence. Using a primary cell-based coculture model, we show that monocyte-derived macrophages (MDM) efficiently transmit a high-multiplicity HIV-1 infection to autologous CD4(+) T cells through a viral envelo...

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Main Authors: Duncan, Christopher J. A., Williams, James P., Schiffner, Torben, Gärtner, Kathleen, Ochsenbauer, Christina, Kappes, John, Russell, Rebecca A., Frater, John, Sattentau, Quentin J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911534/
https://ncbi.nlm.nih.gov/pubmed/24307588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03245-13
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